منابع مشابه
Morphogenesis of the mammalian blastocyst.
The first 4 days of mouse pre-implantation development are characterized by a period of segmentation, including morphogenetic events that are required for the divergence of embryonic and extra-embryonic lineages. These extra-embryonic tissues are essential for the implantation into the maternal uterus and for the development of the foetus. In this review, we first discuss data showing unambiguo...
متن کاملCell death in the mammalian blastocyst.
Cell death is a widespread feature in the blastocysts of many mammals. Isolated cells in both the inner cell mass and the trophectoderm undergo cell death. These dying cells appear morphologically to be undergoing apoptosis. In mouse blastocysts, a wave of cell death is seen in vivo, suggesting that it plays an important role in normal development. However, cell death is increased under subopti...
متن کاملSimulating the Mammalian Blastocyst - Molecular and Mechanical Interactions Pattern the Embryo
Mammalian embryogenesis is a dynamic process involving gene expression and mechanical forces between proliferating cells. The exact nature of these interactions, which determine the lineage patterning of the trophectoderm and endoderm tissues occurring in a highly regulated manner at precise periods during the embryonic development, is an area of debate. We have developed a computational modeli...
متن کاملGene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst
A critical event in mammalian embryo development is construction of an inner cell mass surrounded by a trophoectoderm (a shell of cells that later form extraembryonic structures). We utilize multi-scale, stochastic modeling to investigate the design principles responsible for robust establishment of these structures. This investigation makes three predictions, each supported by our quantitative...
متن کاملLactate production by the mammalian blastocyst: Manipulating the microenvironment for uterine implantation and invasion?
The mammalian blastocyst exhibits a high capacity for aerobic glycolysis, a metabolic characteristic of tumours. It has been considered that aerobic glycolysis is a means to ensure a high carbon flux to fulfil biosynthetic demands. Here, alternative explanations for this pattern of metabolism are considered. Lactate creates a microenvironment of low pH around the embryo to assist the disaggrega...
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ژورنال
عنوان ژورنال: Molecular Reproduction and Development
سال: 2018
ISSN: 1040-452X
DOI: 10.1002/mrd.22862